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Benadryl is a popular antihistamine drug that can be purchased over the counter without a prescription. I am asking whether the long term use makes it less effective. Use Benadryl exactly as directed on the label, or as prescribed by your doctor. Advertisement. By: Johnna Kelly. Benadryl, also known by its generic name, diphenhydramine, is one of the few over-the-counter drugs that veterinarians routinely have owners administer at home. If you contact our Customer Support by one of the methods below, we will be able to assist you in locating the product you are looking for. Like other antihistamines, its primary use is to help reduce symptoms associated with allergies such as sneezing and Ayurslim Weight Regulator Pharmacy R runny nose. Zyrtec, Allegra, and Benadryl are some of the most Can You Buy Benadryl Over The Counter popular Top 5 over the counter drugs that are abused. 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